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Article

SIRT6 Widely Regulates Aging, Immunity, and Cancer

6 Apr 2022

Abstract excerpt

SIRT6 is a member of the Sir2-like family in mammals. Recent structural and biochemical studies have characterized SIRT6 as having deacetylation, defatty-acylation, and mono-ADP-ribosylation activities, which determine its important regulatory roles during physiological and pathological processes. This review focuses mainly on the regulatory functions of SIRT6 in aging, cancer, and, especially, immunity....

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PMID: 35463332
DOI: 10.3389/fonc.2022.861334

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