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Article

Long-range phasing of dynamic, tissue-specific and allele-specific regulatory elements.

Nature genetics - 1 Oct 2022

Battaglia Sofia, Dong Kevin, Wu Jingyi, Chen Zeyu, Najm Fadi J, Zhang Yuanyuan, Moore Molly M, Hecht Vivian, Shoresh Noam, Bernstein Bradley E

Abstract excerpt

Epigenomic maps identify gene regulatory elements by their chromatin state. However, prevailing short-read sequencing methods cannot effectively distinguish alleles, evaluate the interdependence of elements in a locus or capture single-molecule dynamics. Here, we apply targeted nanopore sequencing to profile chromatin accessibility and DNA methylation on contiguous ~100-kb DNA molecules that span loci relevant to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36195755
DOI: 10.1038/s41588-022-01188-8
PMCID: PMC10567064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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