Article
Bridging epigenomics and complex disease: the basics.
Cellular and molecular life sciences : CMLS - 1 May 2013
Teperino Raffaele, Lempradl Adelheid, Pospisilik J Andrew
Abstract excerpt
The DNA sequence largely defines gene expression and phenotype. However, it is becoming increasingly clear that an additional chromatin-based regulatory network imparts both stability and plasticity to genome output, modifying phenotype independently of the genetic blueprint. Indeed, alterations in this "epigenetic" control layer underlie, at least in part, the reason for monozygotic twins being discordant for...
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