Alternative RNA splicing modulates ribosomal composition and determines the spatial phenotype of glioblastoma cells.

doi:10.1038/s41556-022-00994-w

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Article

Alternative RNA splicing modulates ribosomal composition and determines the spatial phenotype of glioblastoma cells.

Nature cell biology - 1 Oct 2022

Larionova Tatyana D, Bastola Soniya, Aksinina Tatiana E, Anufrieva Ksenia S, Wang Jia, Shender Victoria O, Andreev Dmitriy E, Kovalenko Tatiana F, Arapidi Georgij P, Shnaider Polina V, Kazakova Anastasia N, Latyshev Yaroslav A, Tatarskiy Victor V, Shtil Alexander A, Moreau Pascale, Giraud Francis, Li Chaoxi, Wang Yichan, Rubtsova Maria P, Dontsova Olga A, Condro Michael, Ellingson Benjamin M, Shakhparonov Mikhail I, Kornblum Harley I, Nakano Ichiro, Pavlyukov Marat S

Abstract excerpt

Glioblastoma (GBM) is characterized by exceptionally high intratumoral heterogeneity. However, the molecular mechanisms underlying the origin of different GBM cell populations remain unclear. Here, we found that the compositions of ribosomes of GBM cells in the tumour core and edge differ due to alternative RNA splicing. The acidic pH in the core switches before messenger RNA splicing of the ribosomal gene...

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Identifiers

PMID: 36192632
DOI: 10.1038/s41556-022-00994-w
PMCID: PMC10026424

Genes

RPL22L1
SRSF4
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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