Article
Ribosomal Proteins RPS11 and RPS20, Two Stress-Response Markers of Glioblastoma Stem Cells, Are Novel Predictors of Poor Prognosis in Glioblastoma Patients.
PloS one - 1 Jan 2015
Yong William H, Shabihkhani Maryam, Telesca Donatello, Yang Shuai, Tso Jonathan L, Menjivar Jimmy C, Wei Bowen, Lucey Gregory M, Mareninov Sergey, Chen Zugen, Liau Linda M, Lai Albert, Nelson Stanley F, Cloughesy Timothy F, Tso Cho-Lea
Abstract excerpt
Glioblastoma stem cells (GSC) co-exhibiting a tumor-initiating capacity and a radio-chemoresistant phenotype, are a compelling cell model for explaining tumor recurrence. We have previously characterized patient-derived, treatment-resistant GSC clones (TRGC) that survived radiochemotherapy. Compared to glucose-dependent, treatment-sensitive GSC clones (TSGC), TRGC exhibited reduced glucose dependence that favor...
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