Article
Cancer-associated SNRPD3 mutation confers resistance to hypoxia, which is attenuated by DRP1 inhibition.
Biochemical and biophysical research communications - 12 Feb 2024
Satoh Shingo, Miyake Kotaro, Adachi Yuichi, Masuhiro Kentaro, Futami Shinji, Naito Yujiro, Shiroyama Takayuki, Koyama Shohei, Yamaguchi Yuta, Konaka Hachiro, Takamatsu Hyota, Okuzaki Daisuke, Nagatomo Izumi, Takeda Yoshito, Kumanogoh Atsushi
Abstract excerpt
RNA splicing is a fundamental cellular mechanism performed by spliceosomes that synthesise multiple mature RNA isoforms from a single gene. The association between spliceosome abnormality and solid cancers remains largely unknown. Here, we demonstrated that Sm proteins, which are common components of the spliceosomes and constitute the Sm ring, were overexpressed in multiple cancers and their expression levels...
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