Isocitrate dehydrogenase wt and IDHmut adult-type diffuse gliomas display distinct alterations in ribosome biogenesis and 2'O-methylation of ribosomal RNA.

doi:10.1093/neuonc/noad140

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Article

Isocitrate dehydrogenase wt and IDHmut adult-type diffuse gliomas display distinct alterations in ribosome biogenesis and 2'O-methylation of ribosomal RNA.

Neuro-oncology - 8 Dec 2023

Paraqindes Hermes, Mourksi Nour-El-Houda, Ballesta Samantha, Hedjam Jordan, Bourdelais Fleur, Fenouil Tanguy, Picart Thiébaud, Catez Frédéric, Combe Théo, Ferrari Anthony, Kielbassa Janice, Thomas Emilie, Tonon Laurie, Viari Alain, Attignon Valéry, Carrere Marjorie, Perrossier Jessie, Giraud Stéphane, Vanbelle Christophe, Gabut Mathieu, Bergeron Danny, Scott Michelle S, Castro Vega Luis, Magne Nathalie, Huillard Emmanuelle, Sanson Marc, Meyronet David, Diaz Jean-Jacques, Ducray François, Marcel Virginie, Durand Sébastien

Abstract excerpt

BACKGROUND: High-grade adult-type diffuse gliomas (HGGs) constitute a heterogeneous group of aggressive tumors that are mostly incurable. Recent advances highlighting the contribution of ribosomes to cancer development have offered new clinical perspectives. Here, we uncovered that isocitrate dehydrogenase (IDH)wt and IDHmut HGGs display distinct alterations of ribosome biology, in terms of rRNA...

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PMID: 37531290
DOI: 10.1093/neuonc/noad140
PMCID: PMC10708943

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