Article

Re-convolving the compositional landscape of primary and recurrent glioblastoma reveals prognostic and targetable tissue states

2021-07-07

Abstract excerpt

Glioblastoma (GBM) is an aggressive diffusely infiltrating neoplasm that spreads beyond surgical resection margins, where it intermingles with non-neoplastic brain cells. This complex microenvironment harboring infiltrating glioma and non-neoplastic brain cells is the origin of tumor recurrence. Thus, understanding the cellular and molecular features of the glioma microenvironment is therapeutically and prognostic...

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Literature Corpus work: af36e1c9-27fc-5bd9-91f8-b25af6424365
DOI: 10.1101/2021.07.06.451295

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