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Article

A Dynamic rRNA Ribomethylome Drives Stemness in Acute Myeloid Leukemia.

Cancer discovery - 6 Feb 2023

Zhou Fengbiao, Aroua Nesrine, Liu Yi, Rohde Christian, Cheng Jingdong, Wirth Anna-Katharina, Fijalkowska Daria, Göllner Stefanie, Lotze Michelle, Yun Haiyang, Yu Xiaobing, Pabst Caroline, Sauer Tim, Oellerich Thomas, Serve Hubert, Röllig Christoph, Bornhäuser Martin, Thiede Christian, Baldus Claudia, Frye Michaela, Raffel Simon, Krijgsveld Jeroen, Jeremias Irmela, Beckmann Roland, Trumpp Andreas, Müller-Tidow Carsten

Abstract excerpt

The development and regulation of malignant self-renewal remain unresolved issues. Here, we provide biochemical, genetic, and functional evidence that dynamics in ribosomal RNA (rRNA) 2'-O-methylation regulate leukemia stem cell (LSC) activity in vivo. A comprehensive analysis of the rRNA 2'-O-methylation landscape of 94 patients with acute myeloid leukemia (AML) revealed dynamic 2'-O-methylation specifically at...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36259929
DOI: 10.1158/2159-8290.CD-22-0210
PMCID: PMC9900322

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