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Single-cell and spatial transcriptomic insights into glioma cellular heterogeneity and metabolic adaptations

4 Apr 2025

Abstract excerpt

Glioblastoma, one of the most aggressive and heterogeneous malignant tumors, presents significant challenges for clinical management due to its cellular and metabolic complexity. This review integrates recent advancements in single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics to elucidate glioblastoma's cellular heterogeneity and metabolic reprogramming. Diverse cellular subpopulations, including...

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PMID: 40255400
DOI: 10.3389/fimmu.2025.1561388

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