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The short isoform of MS4A7 is a novel player in glioblastoma microenvironment, M2 macrophage polarization, and tumor progression

21 Mar 2023

Abstract excerpt

BACKGROUND: The unique intracranial tumor microenvironment (TME) contributes to the immunotherapy failure for glioblastoma (GBM), thus new functional protein targets are urgently needed. Alternative splicing is a widespread regulatory mechanism by which individual gene can express variant proteins with distinct functions. Moreover, proteins located in the cell plasma membrane facilitate targeted therapies. This...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36944954
DOI: 10.1186/s12974-023-02766-1

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