CbAgo-enriched Cas12a biosensor for cancer mutations screening.

Abstract excerpt

BACKGROUND: Accurate detection of low-frequency DNA mutations in body fluids is essential for cancer monitoring and treatment evaluation. However, the high abundance of wild-type DNA often masks rare mutant signals, making sensitive detection particularly challenging. RESULTS: We developed a screening strategy termed the CbAgo-enriched Cas12a mutation screening system (CECMS). By integrating the single-nucleotide...

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