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Article

STAR-CRISPR: a one-pot ultraspecific CRISPR strategy for rapid, visualized SNV detection and genotyping in point-of-care diagnostics.

Talanta - 1 Nov 2026

Liu Dianwei, Ma Guoxiu, Bai Linlin, Guo Kaiming, Wang Ting, Jiang Zhaoyang, Qian Feng, Wang Yuanchen, Pang Yanan, Zou Wenbin, Wang Rui

Abstract excerpt

Single nucleotide variation (SNV), as a key biomarker for disease diagnosis and personalized treatment, faces challenges in rapid and accurate detection. This study developed a single-tube accelerated recognition of SNVs strategy named STAR-CRISPR, which could accomplish SNV detection within only 20 min. This method integrated isothermal amplification and CRISPR/Cas12b cleavage system in one pot, and results...

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PMID: 42217941
DOI: 10.1016/j.talanta.2026.130036

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