Article
The introduction of mutations in the wild type coxsackievirus B3 (CVB3) IRES RNA leads to different levels of in vitro reduced replicative and translation efficiencies.
PloS one - 1 Jan 2022
Gharbi Jawhar, Almalki Mohammed A, Ben M'hadheb Manel
Abstract excerpt
Coxsackievirus B3 (CVB3) is a principal causative agent of viral myocarditis, meningitis and pancreatitis. There is no vaccine available for clinical use. It has been demonstrated that the primary molecular determinant of virulence phenotype is located in the 5' UTR of the viral genome. Translation initiation of CVB3 RNA is directed by the IRES element situated in the 5'UTR. In the present study, we analyse the...
Topics
- 5' Untranslated Regions
- Animals
- Coxsackievirus Infections
- Enterovirus B, Human
- HeLa Cells
- Humans
- Mice
- Mutation
- Nucleic Acid Conformation
- RNA, Viral
- Virus Replication