Article
The cardiovirulent phenotype of coxsackievirus B3 is determined at a single site in the genomic 5' nontranslated region.
Journal of virology - 1 Aug 1995
Tu Z, Chapman N M, Hufnagel G, Tracy S, Romero J R, Barry W H, Zhao L, Currey K, Shapiro B
Abstract excerpt
We report the construction of chimeric coxsackievirus B3 (CVB3) strains in which sequences of an infectious cDNA copy of a noncardiovirulent CVB3 genome were replaced by the homologous sequences from a cardiovirulent CVB3 genome to identify which of 10 predicted genetic sites determine cardioviru...
Topics
- Animals
- Base Sequence
- Chimera
- Enterovirus B, Human
- HeLa Cells
- Humans
- Male
- Mice
- Mice, Inbred C3H
- Mice, SCID
- Molecular Sequence Data
- Myocarditis
- Phenotype
- Protein Biosynthesis
- RNA, Viral
- Species Specificity