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Article

Mutations in the 5' NTR and the Non-Structural Protein 3A of the Coxsackievirus B3 Selectively Attenuate Myocarditogenicity.

PloS one - 1 Jan 2015

Massilamany Chandirasegaran, Gangaplara Arunakumar, Basavalingappa Rakesh H, Rajasekaran Rajkumar A, Vu Hiep, Riethoven Jean-Jack, Steffen David, Pattnaik Asit K, Reddy Jay

Abstract excerpt

The 5' non-translated region (NTR) is an important molecular determinant that controls replication and virulence of coxsackievirus B (CVB)3. Previous studies have reported many nucleotide (nt) sequence differences in the Nancy strain of the virus, including changes in the 5' NTR with varying degrees of disease severity. In our studies of CVB3-induced myocarditis, we sought to generate an infectious clone of the...

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Identifiers

PMID: 26098885
DOI: 10.1371/journal.pone.0131052
PMCID: PMC4476614

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Source receipt: pubmed, retrieved 7 Sept 2026.

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