Article
Characterization of an infectious cDNA copy of the genome of a naturally occurring, avirulent coxsackievirus B3 clinical isolate.
The Journal of general virology - 1 Jan 2005
Lee C-K, Kono K, Haas E, Kim K-S, Drescher K M, Chapman N M, Tracy S
Abstract excerpt
Group B coxsackieviruses (CVB) cause numerous diseases, including myocarditis, pancreatitis, aseptic meningitis and possibly type 1 diabetes. To date, infectious cDNA copies of CVB type 3 (CVB3) genomes have all been derived from pathogenic virus strains. An infectious cDNA copy of the well-characterized, non-pathogenic CVB3 strain GA genome was cloned in order to facilitate mapping of the CVB genes that...
Topics
- 5' Untranslated Regions
- Animals
- Base Sequence
- DNA, Complementary
- Disease Models, Animal
- Enterovirus B, Human
- Enterovirus Infections
- Genome, Viral
- Humans
- Male
- Mice
- Mice, Inbred C3H
- Molecular Sequence Data
- Myocarditis