Article
Oral Immunization with the C488A Live-Attenuated Mutant of Coxsackievirus B4E2 (CVB4E2) Induces Potent Immune Response and Protects Balb/c Mice Against Lethal Infection.
Viruses - 11 Feb 2026
Gharbi Jawhar, Hadj Hassine Ikbel, Hassine Mouna, Al-Bashir Anwar, Al-Chahri Reem, Al-Yami Ameera, Al-Malki Mohamed, Chatti Noureddine, Hober Didier, M'hadheb Manel Ben
Abstract excerpt
BACKGROUND/OBJECTIVES: Coxsackievirus B4 (CVB4), a member of the Enterovirus genus and the Picornaviridae family, is a significant pathogen causing several human diseases such as pancreatitis, myocarditis, cardiomyopathy and type 1 diabetes. Despite its clinical impact, no vaccines or specific antiviral therapies are currently available. This study investigates the attenuation of CVB4 virulence through targeted...
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