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Article

Role of GNRA motif mutations within stem-loop V of internal ribosome entry segment in coxsackievirus B3 molecular attenuation.

Journal of molecular microbiology and biotechnology - 1 Jan 2008

M'hadheb-Gharbi Manel Ben, El Hiar Raïda, Paulous Sylvie, Jaïdane Hela, Aouni Mahjoub, Kean Katherine M, Gharbi Jawhar

Abstract excerpt

The lengthy 5' nontranslated region of coxsackievirus B3 (CVB3) forms a highly ordered secondary structure containing an internal ribosome entry segment (IRES), which plays an important role in controlling viral translation and pathogenesis. The stem-loop V (SL-V) of this IRES contains a large lateral bulge loop which encompasses two conserved GNRA motifs. In this study, we analyzed the effects of point mutations...

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PMID: 17693702
DOI: 10.1159/000107369

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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