Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The stem loop II within the 5' nontranslated region of clinical coxsackievirus B3 genomes determines cardiovirulence phenotype in a murine model.

The Journal of infectious diseases - 15 May 2003

Dunn James J, Bradrick Shelton S, Chapman Nora M, Tracy Steven M, Romero José R

Abstract excerpt

Coxsackievirus B3 (CVB3) is a principal viral cause of acute myocarditis in humans and has been implicated in the pathogenesis of dilated cardiomyopathy. It has been demonstrated elsewhere that, for 2 wild-type CVB3 strains, the primary molecular determinant of cardiovirulence phenotype localizes to the 5' nontranslated region (5' NTR). Here in this study, through construction of CVB3 chimeras, the predicted stem...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5' Untranslated Regions
Share to Enterovirus B, Human

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enterovirus Infections

Share to Mice, Inbred C3H

Share to Myocarditis

Share to Myocardium

Share to Nucleic Acid Conformation

Share to Virus Replication

Source

Identifiers

PMID: 12721935
DOI: 10.1086/374877

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The stem loop II within the 5' nontranslated region of clinical coxsackievirus B3 genomes determines cardiovirulence phenotype in a murine model.PMID 12721935Read ↗

Molecular analysis of the role of IRES stem-loop V in replicative capacities and translation efficiencies of Coxsackievirus B3 mutants.Semantic proximity Read ↗

The cardiovirulent phenotype of coxsackievirus B3 is determined at a single site in the genomic 5' nontranslated region.Semantic proximity Read ↗

Genomic determinants of cardiovirulence in coxsackievirus B3 clinical isolates: localization to the 5' nontranslated region.Semantic proximity Read ↗

Genetics of coxsackievirus B3 cardiovirulence.Semantic proximity Read ↗

5′-Terminal Deletions Occur in Coxsackievirus B3 during Replication in Murine Hearts and Cardiac Myocyte Cultures and Correlate with Encapsidation of Negative-Strand Viral RNASemantic proximity Read ↗

The 3A protein of coxsackievirus B3 acts as a viral suppressor of RNA interferenceSemantic proximity Read ↗

Nucleotide sequence of an attenuated mutant of coxsackievirus B3 compared with the cardiovirulent wildtype: assessment of candidate mutations by analysis of a revertant to cardiovirulence.Semantic proximity Read ↗

Role of RNA Domain Structure and Orientation in the Coxsackievirus B3 Virulence Phenotype.Semantic proximity Read ↗

The substitution U475 --> C with Sabin3-like mutation within the IRES attenuate Coxsackievirus B3 cardiovirulence.Semantic proximity Read ↗

Characterization of an infectious cDNA copy of the genome of a naturally occurring, avirulent coxsackievirus B3 clinical isolate.Semantic proximity Read ↗

Phenotypic characterization of three phylogenetically conserved stem-loop motifs in the mengovirus 3' untranslated region.Semantic proximity Read ↗

Complete nucleotide sequence of infectious Coxsackievirus B3 cDNA: two initial 5' uridine residues are regained during plus-strand RNA synthesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.