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A Single Mutation in the Cryptic AUG (cAUG) Affects In Vitro Translation and Replication Efficiencies and In Vivo Virulence of Coxsackievirus B3 (CVB3).

Current microbiology - 16 Aug 2022

Ben Youssef Ahlem, Gharbi Jawhar, George Biju, Das Saumitra, Ben M'hadheb Manel

Abstract excerpt

The 5'UTR of the genomic RNA of CVB3, unusually long and rich on highly structured secondary structure, contains a conserved cis acting RNA element named the cryptic AUG (cAUG), where the cellular 48S complex is formed. In this study, we investigate the role of this cAUG in CVB3 translation, replication, and virulence. Mutant viral sub-genomic replicon RNA was constructed by site-directed mutagenesis. We...

Topics

5' Untranslated Regions
Enterovirus B, Human
HeLa Cells
Humans
Mutation
Nucleic Acid Conformation
Protein Biosynthesis
RNA, Viral
RNA-Binding Proteins
Virulence
Virus Replication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35972696
DOI: 10.1007/s00284-022-02986-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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