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Article

Energy landscape reshaped by strain-specific mutations underlies epistasis in NS1 evolution of influenza A virus.

Nature communications - 1 Oct 2022

Kim Iktae, Dubrow Alyssa, Zuniga Bryan, Zhao Baoyu, Sherer Noah, Bastiray Abhishek, Li Pingwei, Cho Jae-Hyun

Abstract excerpt

Elucidating how individual mutations affect the protein energy landscape is crucial for understanding how proteins evolve. However, predicting mutational effects remains challenging because of epistasis-the nonadditive interactions between mutations. Here, we investigate the biophysical mechanism of strain-specific epistasis in the nonstructural protein 1 (NS1) of influenza A viruses (IAVs). We integrate...

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Identifiers

PMID: 36182933
DOI: 10.1038/s41467-022-33554-9
PMCID: PMC9526705

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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