Article
Mutational effects on stability are largely conserved during protein evolution.
Proceedings of the National Academy of Sciences of the United States of America - 24 Dec 2013
Ashenberg Orr, Gong L Ian, Bloom Jesse D
Abstract excerpt
Protein stability and folding are the result of cooperative interactions among many residues, yet phylogenetic approaches assume that sites are independent. This discrepancy has engendered concerns about large evolutionary shifts in mutational effects that might confound phylogenetic approaches. Here we experimentally investigate this issue by introducing the same mutations into a set of diverged homologs of the...
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