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Article

Mutational effects on stability are largely conserved during protein evolution.

Proceedings of the National Academy of Sciences of the United States of America - 24 Dec 2013

Ashenberg Orr, Gong L Ian, Bloom Jesse D

Abstract excerpt

Protein stability and folding are the result of cooperative interactions among many residues, yet phylogenetic approaches assume that sites are independent. This discrepancy has engendered concerns about large evolutionary shifts in mutational effects that might confound phylogenetic approaches....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24324165
DOI: 10.1073/pnas.1314781111
PMCID: PMC3876214

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24324165-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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