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Article

Mutation and Epistasis in Influenza Virus Evolution.

Viruses - 3 Aug 2018

Lyons Daniel M, Lauring Adam S

Abstract excerpt

Influenza remains a persistent public health challenge, because the rapid evolution of influenza viruses has led to marginal vaccine efficacy, antiviral resistance, and the annual emergence of novel strains. This evolvability is driven, in part, by the virus's capacity to generate diversity through mutation and reassortment. Because many new traits require multiple mutations and mutations are frequently combined...

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Topics

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Share to Epistasis, Genetic
Share to Genetic Fitness
Share to Hemagglutinin Glycoproteins, Influenza Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Influenza A Virus, H1N1 Subtype

Share to Influenza A Virus, H3N2 Subtype

Share to Influenza, Human

Share to Orthomyxoviridae

Share to Reassortant Viruses

Source

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Identifiers

PMID: 30081492
DOI: 10.3390/v10080407
PMCID: PMC6115771

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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