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Article

Stability-mediated epistasis constrains the evolution of an influenza protein.

eLife - 14 May 2013

Gong Lizhi Ian, Suchard Marc A, Bloom Jesse D

Abstract excerpt

John Maynard Smith compared protein evolution to the game where one word is converted into another a single letter at a time, with the constraint that all intermediates are words: WORD→WORE→GORE→GONE→GENE. In this analogy, epistasis constrains evolution, with some mutations tolerated only after the occurrence of others. To test whether epistasis similarly constrains actual protein evolution, we created all...

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Identifiers

PMID: 23682315
DOI: 10.7554/eLife.00631
PMCID: PMC3654441

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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