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Article

APOE ɛ4 allele and TOMM40-APOC1 variants jointly contribute to survival to older ages.

Aging cell - 1 Dec 2022

Kulminski Alexander M, Jain-Washburn Ethan, Philipp Ian, He Liang, Loika Yury, Loiko Elena, Bagley Olivia, Ukraintseva Svetlana, Yashin Anatoliy, Arbeev Konstantin, Stallard Eric, Feitosa Mary F, Schupf Nicole, Christensen Kaare, Culminskaya Irina

Abstract excerpt

Age-related diseases characteristic of post-reproductive life, aging, and life span are the examples of polygenic non-Mendelian traits with intricate genetic architectures. Polygenicity of these traits implies that multiple variants can impact their risks independently or jointly as combinations of specific variants. Here, we examined chances to live to older ages, 85 years and older, for carriers of compound...

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PMID: 36330582
DOI: 10.1111/acel.13730
PMCID: PMC9741507

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