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Spatio-temporal analysis of prostate tumors in situ suggests pre-existence of treatment-resistant clones

17 Sept 2022

Abstract excerpt

The molecular mechanisms underlying lethal castration-resistant prostate cancer remain poorly understood, with intratumoral heterogeneity a likely contributing factor. To examine the temporal aspects of resistance, we analyze tumor heterogeneity in needle biopsies collected before and after treatment with androgen deprivation therapy. By doing so, we are able to couple clinical responsiveness and morphological...

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PMID: 36115838
DOI: 10.1038/s41467-022-33069-3

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