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Article

RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance

18 Sept 2015

Abstract excerpt

Prostate cancer is initially responsive to androgen deprivation, but the effectiveness of androgen receptor (AR) inhibitors in recurrent disease is variable. Biopsy of bone metastases is challenging; hence, sampling circulating tumor cells (CTCs) may reveal drug-resistance mechanisms. We established single-cell RNA-sequencing (RNA-Seq) profiles of 77 intact CTCs isolated from 13 patients (mean six CTCs per...

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PMID: 26383955
DOI: 10.1126/science.aab0917

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