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Article

Transcriptional mediators of treatment resistance in lethal prostate cancer

2020-03-20

Abstract excerpt

<h4>ABSTRACT</h4> Metastatic castration resistant prostate cancer (mCRPC) is primarily treated with therapies that prevent transcriptional activity of the androgen receptor (AR), cause DNA damage, or prevent cell division. Clinical resistance to these therapies, including second-generation androgen-targeting compounds such as enzalutamide and abiraterone, is nearly universal. Other treatment modalities, including...

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Identifiers and source

Literature Corpus work
8dc498f9-d03c-5fa5-9bed-63e2faf68138
DOI
10.1101/2020.03.19.998450
Open publication

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