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Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse

6 Sept 2021

Abstract excerpt

Prostate cancer is heterogeneous and patients would benefit from methods that stratify those who are likely to respond to systemic therapy. Here, we employ single-cell assays for transposase-accessible chromatin (ATAC) and RNA sequencing in models of early treatment response and resistance to enzalutamide. In doing so, we identify pre-existing and treatment-persistent cell subpopulations that possess regenerative...

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PMID: 34489465
DOI: 10.1038/s41467-021-25624-1

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