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Article

Clinical value of R-spondins in triple-negative and metaplastic breast cancers

4 May 2017

Abstract excerpt

RSPO ligands, activators of the Wnt/ β -catenin pathway, are overexpressed in different cancers. The objective of this study was to investigate the role of RSPOs in breast cancer (BC). Expression of RSPO and markers of various cancer pathways were measured in breast tumours and cell lines by qRT–PCR. The effect of RSPO on the Wnt/ β -catenin pathway activity was determined by luciferase assay, western blotting,...

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Identifiers

PMID: 28472820
DOI: 10.1038/bjc.2017.131

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