Article

Spatial transcriptome analysis of the human developmental haematopoietic stem cell niche

2020-01-01

Abstract excerpt

During human embryonic development the first definitive haematopoietic stem cells (HSCs) arise in the aorta-gonad-mesonephros (AGM) region between Carnegie stages (CS) 13 to 17. More specifically, these HSCs are considered to derive from the endothelial cells of the dorsal aorta which undergo an endothelial-to-haematopoietic transition and bud into the lumen to form intra-aortic clusters of haematopoietic cells. T...

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Literature Corpus work: 3f7ce7a4-bcaf-5280-b842-c1efc543e1ec
DOI: 10.7488/era/186

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