Article

Human vein-to-artery endothelial cell fate transition is driven by VEGF/ERK activation and PI3K inhibition

2025-12-19

Abstract excerpt

<h4>ABSTRACT</h4> Artery endothelial cells (ECs) arise through different pathways, including differentiation from mesodermal cells (vasculogenesis) or from already established vein or capillary plexus ECs (angiogenesis), the latter being most common during embryonic development and regeneration. Understanding the vein-to-artery (v2a) transition could improve revascularization therapies, but progress is limited by...

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Literature Corpus work: bc8a2b7d-4a15-5a99-a337-714c300a022c
DOI: 10.64898/2025.12.17.694993

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