Article
DACH1 stimulates shear stress-guided endothelial cell migration and coronary artery growth through the CXCL12-CXCR4 signaling axis.
Genes & development - 1 Jul 2017
Chang Andrew H, Raftrey Brian C, D'Amato Gaetano, Surya Vinay N, Poduri Aruna, Chen Heidi I, Goldstone Andrew B, Woo Joseph, Fuller Gerald G, Dunn Alexander R, Red-Horse Kristy
Abstract excerpt
Sufficient blood flow to tissues relies on arterial blood vessels, but the mechanisms regulating their development are poorly understood. Many arteries, including coronary arteries of the heart, form through remodeling of an immature vascular plexus in a process triggered and shaped by blood flow. However, little is known about how cues from fluid shear stress are translated into responses that pattern artery...
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