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Article

Systematic engineering of 3D pluripotent stem cell niches to guide blood development.

Biomaterials - 1 Feb 2012

Purpura Kelly A, Bratt-Leal Andrés M, Hammersmith Katy A, McDevitt Todd C, Zandstra Peter W

Abstract excerpt

Pluripotent stem cells (PSC) provide insight into development and may underpin new cell therapies, yet controlling PSC differentiation to generate functional cells remains a significant challenge. In this study we explored the concept that mimicking the local in vivo microenvironment during mesoderm specification could promote the emergence of hematopoietic progenitor cells from embryonic stem cells (ESCs)....

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Identifiers

PMID: 22079776
DOI: 10.1016/j.biomaterials.2011.10.051
PMCID: PMC4280365

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BMP4
TPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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