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Differential requirement for DICER1 activity during the development of mitral and tricuspid valves

10 Aug 2022

Abstract excerpt

Mitral and tricuspid valves are essential for unidirectional blood flow in the heart. They are derived from similar cell sources, and yet congenital dysplasia affecting both valves is clinically rare, suggesting the presence of differential regulatory mechanisms underlying their development. Here, we specifically inactivated Dicer1 in the endocardium during cardiogenesis and found that Dicer1 deletion caused...

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PMID: 35946425
DOI: 10.1242/jcs.259783

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