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Article

Conditional <i>Dicer</i> Gene Deletion in the Postnatal Myocardium Provokes Spontaneous Cardiac Remodeling

23 Sept 2008

Abstract excerpt

BACKGROUND: Dicer, an RNAse III endonuclease critical for processing of pre-microRNAs (miRNAs) into mature 22-nucleotide miRNAs, has proven a useful target to dissect the significance of miRNAs biogenesis in mammalian biology. METHODS AND RESULTS: To circumvent the embryonic lethality associated with germline null mutations for Dicer, we triggered conditional Dicer loss through the use of a tamoxifen-inducible...

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PMID: 18809798
DOI: 10.1161/circulationaha.108.769984

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