Article
Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure.
Proceedings of the National Academy of Sciences of the United States of America - 12 Feb 2008
Chen Jian-Fu, Murchison Elizabeth P, Tang Ruhang, Callis Thomas E, Tatsuguchi Mariko, Deng Zhongliang, Rojas Mauricio, Hammond Scott M, Schneider Michael D, Selzman Craig H, Meissner Gerhard, Patterson Cam, Hannon Gregory J, Wang Da-Zhi
Abstract excerpt
Cardiovascular disease is the leading cause of human morbidity and mortality. Dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy associated with heart failure. Here, we report that cardiac-specific knockout of Dicer, a gene encoding a RNase III endonuclease essential for microRNA (miRNA) processing, leads to rapidly progressive DCM, heart failure, and postnatal lethality. Dicer mutant mice...
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