Back to search

Article

A human cell model of cardiac pathophysiological valvulogenesis

2018-08-22

Abstract excerpt

Genetically modified mice have advanced our understanding of valve development and related pathologies. Yet, little is known regarding human valvulogenesis in health and diseases. Genuine human in vitro models that reproduce valvular (patho)biology are thus needed. We here developed a human pluripotent stem cell-derived model fit to decode the early steps of human valvulogenesis and to recapitulate valve disease...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
cff5d659-d9f7-55c0-b01a-d5b524e6812f
DOI
10.1101/397422
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A human cell model of cardiac pathophysiological valvulogenesisDOI 10.1101/397422
Human pre-valvular endocardial cells derived from pluripotent stem cells recapitulate cardiac pathophysiological valvulogenesisSemantic proximity
Feeder-free generation and characterization of endocardial and cardiac valve cells from human pluripotent stem cellsSemantic proximity
Feeder-Free Generation of Endocardial and Cardiac Valve Cells from Human Pluripotent Stem CellsSemantic proximity
Generation of Valvular Interstitial Cells from Human Pluripotent Stem CellsSemantic proximity
Cellular Landscapes of Nondiseased Human Cardiac Valves From End-Stage Heart Failure–Explanted HeartSemantic proximity
Multi-chamber cardioids unravel human heart development and cardiac defectsSemantic proximity
Developmental basis of adult cardiovascular diseases: valvular heart diseases.Semantic proximity
Generation of Heart Organoids Modeling Early Human Cardiac Development Under Defined ConditionsSemantic proximity
Valvulogenesis: the moving targetSemantic proximity
Induced pluripotent stem cells for cardiovascular disease: from product-focused disease modeling to process-focused disease discovery.Semantic proximity
Multi-chamber cardioids unravel human heart development and cardiac defectsSemantic proximity
Developmental Mechanisms of Aortic Valve Malformation and DiseaseSemantic proximity
Select a neighboring publication to make it the new centre.