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Article

miRNA-processing enzyme Dicer is necessary for cardiac outflow tract alignment and chamber septation

14 Dec 2009

Abstract excerpt

MicroRNAs (miRNAs) have previously been implicated in a number of developmental processes, including development of the ventricular myocardium of the heart. To determine what, if any, additional roles miRNAs play in cardiogenesis, we deleted the miRNA-processing enzyme Dicer specifically in the developing murine heart. Embryos lacking cardiac Dicer lived longer than reported in previous studies using different...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 20018673
DOI: 10.1073/pnas.0912870107

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