Article

Differential Requirement of DICER1 Activity during Development of Mitral and Tricuspid Valves

2022-01-12

Abstract excerpt

Mitral and tricuspid valves are essential for unidirectional blood flow in the heart. They are derived from similar cell sources, and yet congenital dysplasia affecting both valves is clinically rare, suggesting the presence of differential regulatory mechanisms underlying their development. We specifically inactivated Dicer1 in the endocardium during cardiogenesis, and unexpectedly found that Dicer1 -deletion c...

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Literature Corpus work: 53725a4d-395d-5f48-9d05-9d1c093c6a78
DOI: 10.1101/2022.01.10.475694

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