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Article

Developmental basis of adult cardiovascular diseases: valvular heart diseases.

Annals of the New York Academy of Sciences - 1 Feb 2010

Markwald Roger R, Norris Russell A, Moreno-Rodriguez Ricardo, Levine Robert A

Abstract excerpt

In this chapter, we review the working hypothesis that the roots of adult valvular heart disease (VHD) lie in embryonic development. Valvulogenesis is a complex process in which growth factors signal the process of endocardium-to-mesenchyme transformation (EMT) resulting in formation of prevalvul...

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Identifiers

PMID: 20201901
DOI: 10.1111/j.1749-6632.2009.05098.x
PMCID: PMC3371607

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20201901-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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