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Article

Human Variation in DNA Repair, Immune Function, and Cancer Risk.

Frontiers in immunology - 1 Jan 2022

Cheong Ana, Nagel Zachary D

Abstract excerpt

DNA damage constantly threatens genome integrity, and DNA repair deficiency is associated with increased cancer risk. An intuitive and widely accepted explanation for this relationship is that unrepaired DNA damage leads to carcinogenesis due to the accumulation of mutations in somatic cells. But DNA repair also plays key roles in the function of immune cells, and immunodeficiency is an important risk factor for...

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Identifiers

PMID: 35935942
DOI: 10.3389/fimmu.2022.899574
PMCID: PMC9354717

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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