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Article

Inborn Errors of Immunity caused by defects of the DNA damage response pathways

2022-03-08

Abstract excerpt

Several inborn errors of immunity are caused by defects in the general DNA repair machinery as exemplified by the T-B- RS-SCID condition owing to impaired resolution of programmed DNA double strands breaks introduced by RAG1/2 during V(D)J recombination. The genome instability generally associated with these conditions results in an increased propensity to develop malignancies requiring genotoxic based anti-cancer...

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Literature Corpus work
d372fade-372f-504d-aa12-433e844b733d
DOI
10.22541/au.164672628.83605152/v1
Open publication

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Inborn Errors of Immunity caused by defects of the DNA damage response pathwaysDOI 10.22541/au.164672628.83605152/v1
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