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The Role of DNA Repair in Immunological Diversity: From Molecular Mechanisms to Clinical Ramifications

1 Apr 2022

Abstract excerpt

An effective humoral immune response necessitates the generation of diverse and high-affinity antibodies to neutralize pathogens and their products. To generate this assorted immune repertoire, DNA damage is introduced at specific regions of the genome. Purposeful genotoxic insults are needed for the successful completion of multiple immunological diversity processes: V(D)J recombination, class-switch...

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PMID: 35432317
DOI: 10.3389/fimmu.2022.834889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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