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Article

Immunological disorders and DNA repair.

Mutation research - 30 Nov 2002

O'Driscoll Mark, Jeggo Penny

Abstract excerpt

Cellular DNA continuously incurs damage and a range of damage response mechanisms function to maintain genomic integrity in the face of this onslaught. During the development of the immune response, the cell utilises three defined processes, V(D)J recombination, class switch recombination and somatic hypermutation, to create genetic diversity in developing T and B cells. Curiously, the damage response mechanisms...

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Source

Identifiers

PMID: 12427534
DOI: 10.1016/s0027-5107(02)00221-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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