Immunodeficiency associated with DNA repair defects

Abstract excerpt

Cellular DNA is subjected to an onslaught of damaging insults which threaten cellular control and replication. It is therefore unsurprising that a plethora of damage response mechanisms operate to maintain genomic stability. These include processes that recognize and repair the damage, cell cycle checkpoints that prevent cell cycle progression in the presence of damage, and mechanisms, such as apoptosis, that...

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