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Plasma IL-6 levels and their association with brain health and dementia risk: A population-based cohort study.

Brain, behavior, and immunity - 1 Aug 2024

Zhao Zhengyang, Zhang Jiashuo, Wu Yulu, Xie Min, Tao Shiwan, Lv Qiuyue, Wang Qiang

Abstract excerpt

BACKGROUND: Recent studies have associated immune abnormalities with dementia. IL-6 is a crucial cytokine in inflammatory responses, and recent evidence has linked elevated IL-6 levels to changes in brain structure and cognitive decline. However, the connection between IL-6 levels, cognition, brain volumes, and dementia risk requires exploration in large prospective cohorts. METHODS: This study utilized a...

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PMID: 38897328
DOI: 10.1016/j.bbi.2024.06.014

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