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Extrachromosomal circular DNA: a new potential role in cancer progression

10 Jun 2021

Abstract excerpt

Extrachromosomal circular DNA (eccDNA) is considered a circular DNA molecule that exists widely in nature and is independent of conventional chromosomes. eccDNA can be divided into small polydispersed circular DNA (spcDNA), telomeric circles (t-circles), microDNA, and extrachromosomal DNA (ecDNA) according to its size and sequence. Multiple studies have shown that eccDNA is the product of genomic instability, has...

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PMID: 34112178
DOI: 10.1186/s12967-021-02927-x

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