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Innovative insights into extrachromosomal circular DNAs in gynecologic tumors and reproduction

26 May 2023

Abstract excerpt

Originating but free from chromosomal DNA, extrachromosomal circular DNAs (eccDNAs) are organized in circular form and have long been found in unicellular and multicellular eukaryotes. Their biogenesis and function are poorly understood as they are characterized by sequence homology with linear DNA, for which few detection methods are available. Recent advances in high-throughput sequencing technologies have...

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PMID: 37233789
DOI: 10.1093/procel/pwad032

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